PO-02-086 A NOVEL ANTIBIOTIC DELIVERY APPROACH FOR SALVAGE OF CARDIOVASCULAR-IMPLANTABLE ELECTRONIC DEVICES WITH LOCALIZED INFECTION
نویسندگان
چکیده
Present guidelines endorse complete removal of cardiovascular-implantable electronic devices (pacemakers/defibrillators), including extraction intracardiac electrodes, not only for systemic infections but also localized “pocket infections.” We evaluated the efficacy delivering “Continuous, In-situ-Targeted, ultra-high concentration Antibiotics” (CITA) into infected subcutaneous device-pocket, obviating need device/lead-extraction. The CITA-Group consisted 80 patients with pocket infection who were treated CITA during 2007-2021. Of them, nine declined lead-extraction because prohibitive operative risk, and six had questionable indications extraction. remaining 65 infection, eligible opted treatment, compared to 81 similar characteristics underwent device/lead-extraction as primary therapy. Eighty was curative in 85% (68/80) patients, remained free (median follow-up: 3 years, interquartile range 1 – 6.8 years). In case-control study vs. device/lead extraction, cure rates higher after than [96.2%; (78/81) 84.6%; (55/65), p=0.027]. However, serious complications [12 (14.8%) (1.5%), p=0.005]. All-cause 1-month 1-year mortality (0% 3.7%, p=0.25 12.3% 13.6%, p=1.00, respectively). Extraction avoided 90.8% (59/65) extraction-eligible CITA. is a safe effective alternative are unsuitable or unwilling undergo
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2023
ISSN: ['1556-3871', '1547-5271']
DOI: https://doi.org/10.1016/j.hrthm.2023.03.864